We found Mayo to a be small hometown town, with folks that will spend time and talk with you, but not much to see in the town. We were interested in historical (100+ year old buildings) and to capture the House of Seven Gables (torn down). However, read the history here. Below are several photos to capture the area. Lots of renovation ongoing - we will drive through again.
From 'Desolation Florida' ... "There's not much to the town of Mayo, Florida. It's the county seat of Lafayette County, and has a population of around 1300. It's located along highway 27, which connects High Springs (where I live) to towns further to the west. I've certainly driven through Mayo quite a few times as an adult, although I've only stopped once - and that was in order to take pictures for this blog. Modern day Mayo consists of a decaying old downtown, paralleling highway 27."