The depot is a typical example of a small town railroad station, with a waiting room, ticket office, and freight room. It was designed in a Mediterranean Revival style, with stucco walls, red tile roof, and a central tower with a clock. The interior of the depot features terrazzo floors, original fixtures, and a waiting room with a fireplace.
The Zephyrhills Train Depot continued to serve passengers until 1971, when passenger service on the line was discontinued. The station was then used as a freight depot until it was closed in the late 1980s. In 1993, the station was listed on the National Register of Historic Places and was later restored and renovated as a community center.